HUMAN CYTOMEGALOVIRUS IE2 BOTH ACTIVATES AND REPRESSES INITIATION AND MODULATES ELONGATION IN A CONTEXT-DEPENDENT MANNER

Human Cytomegalovirus IE2 Both Activates and Represses Initiation and Modulates Elongation in a Context-Dependent Manner

ABSTRACT Human cytomegalovirus (HCMV) immediate-early 2 (IE2) protein is a multifunctional transcription factor that is essential for lytic HCMV infection.IE2 functions as an activator of Wool Socks viral early genes, negatively regulates its own promoter, and is required for viral replication.The mechanisms by which IE2 executes these distinct fun

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Cryptococcus neoformans urease affects the outcome of intracellular pathogenesis by modulating phagolysosomal pH.

Cryptococcus neoformans is a facultative intracellular pathogen and its interaction with macrophages is a key event Foot Pad determining the outcome of infection.Urease is a major virulence factor in C.neoformans but its role during macrophage interaction has not been characterized.Consequently, we analyzed the effect of urease on fungal-macrophage

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